Semaglutide + B12
A once-weekly GLP-1 medication that quiets appetite and steadies blood sugar, compounded with vitamin B12.
The basics
Semaglutide mimics GLP-1, a hormone your intestine releases after a meal. It tells your brain you've had enough, slows how fast your stomach empties, and helps your pancreas release insulin when blood sugar rises.
In the STEP 1 trial, adults with obesity who took the full weekly dose lost an average of about 15 percent of their body weight over 68 weeks. We start low and move up slowly, because most of the nausea and reflux people report comes from climbing too fast.
We review the studies, the potential uses and benefits, and the open questions in our research post, Will You Need a GLP-1 Forever? What Happens When You Stop.
What the evidence looks like
Strong. Semaglutide has large randomized trials for weight loss, type 2 diabetes, and cardiovascular risk reduction. The trials also show that weight returns after stopping unless the underlying habits and metabolism change.
Why patients ask about it
- Weight loss when diet and exercise alone have stalled
- Blood sugar control and insulin resistance
- Quieting constant food noise and cravings
Good to know
- FDA-approved as Ozempic, Wegovy, and Rybelsus. The compounded semaglutide with B12 we prescribe is not FDA-approved.
- Common side effects are nausea, constipation, and reflux, usually during dose increases.
- Not for anyone with a personal or family history of medullary thyroid carcinoma or MEN2, or during pregnancy.
Will You Need a GLP-1 Forever? What Happens When You Stop
GLP-1 medications work while you take them. The harder truth is what happens when you stop, and why a lasting result depends on what you build during treatment.
Read the articleRelated on our formulary
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